Publications by authors named "G Malamut"
Thoracic manifestations of inflammatory bowel disease (IBD) are rare, occurring in less than 1% of patients. Unlike most other extra-intestinal manifestations, they predominate in patients with ulcerative colitis rather than in Crohn's disease. In most patients, thoracic involvement follows the onset of IBD by several years.
View Article and Find Full Text PDFBackground/aim: We aimed to assess gastrointestinal cancers risks in a large cohort of individuals with primary antibody deficiency (PAD) and their association with risk of autoimmune and inflammatory gastrointestinal diseases.
Methods: Investigating a French national database of inpatient admissions between 2010 and 2018, we identified 12,748 patients with PAD and 38,244 control non-exposed individuals. We performed multiple exposed-non-exposed studies using conditional logistic regression.
Nonresponsive celiac disease (CeD) is relatively common. It is generally attributed to persistent gluten exposure and resolves after correction of diet errors. However, other complications of CeD and disorders clinically mimicking CeD need to be excluded.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effectiveness of adalimumab (ADA) in treating intra-abdominal abscesses in patients with Crohn's disease, specifically those who avoided surgery with prior successful abscess resolution.
- Conducted over two years with 117 eligible patients, the study found that 74% of participants achieved ADA success at 24 weeks, and 72.9% maintained success without relapse or the need for surgery at 104 weeks.
- Key factors linked to ADA failure included previous abscess drainage, longer disease duration, and inflammatory changes in mesenteric fat, highlighting the importance of proper abscess management before starting ADA treatment.