One-carbon metabolism and schizophrenia: current challenges and future directions.

Schizophrenia is a heterogeneous disease generally considered to result from a combination of heritable and environmental factors. Although its pathophysiology has not been fully determined, biological studies support the involvement of several possible components including altered DNA methylation, abnormal glutamatergic transmission, altered mitochondrial function, folate deficiency and high maternal homocysteine levels. Although these factors have been explored separately, they all involve one-carbon (C1) metabolism.

Extensive polycistronism and antisense transcription in the mammalian Hox clusters.

The Hox clusters play a crucial role in body patterning during animal development. They encode both Hox transcription factor and micro-RNA genes that are activated in a precise temporal and spatial sequence that follows their chromosomal order. These remarkable collinear properties confer functional unit status for Hox clusters.

Peer review--the newcomers' perspective.

The World Academy of Young Scientists argue that double blind peer-review will generate a better perception of fairness and equality in global scientific funding and publishing