Publications by authors named "G Mahalakshmi"
Article Synopsis
- - Gemcitabine is a cancer drug effective against tumors like pancreatic and lung cancers, but its effectiveness has been declining due to genetic instability, prompting research into gene polymorphisms that may affect drug metabolism.
- - This study analyzed gene polymorphism frequencies related to gemcitabine metabolism in healthy and lung cancer patients from Southern India, utilizing real-time polymerase chain reaction to genotype 184 healthy individuals and 123 lung cancer patients.
- - Results showed significant differences in allele frequencies for specific SNPs between the South Indian population and the 1000 Genomes Project, with one SNP showing a potential protective effect against lung cancer.
Article Synopsis
- The study focuses on the rising prevalence of lung cancer, particularly non-small cell lung cancer, and the challenges posed by drug resistance and toxicity in treatments involving gemcitabine.
- It involved 184 healthy volunteers and 123 cancer patients in Southern India, using advanced techniques like RT-PCR to analyze genetic variants that may affect treatment outcomes.
- Key findings revealed a minor allele frequency of a specific SNP (NRF2-617 C>A) among the healthy population, with no significant gender differences, suggesting genetic variants might influence the effectiveness and safety of gemcitabine therapy in lung cancer patients.
Introduction: Several factors influence transmission of 2019-nCoV from mother to fetus during pregnancy, thus the dynamics of vertical transmission is unclear. The role of cellular protective factors, namely a 90 KDa glycoprotein, Early pregnancy-associated protein (Epap-1), expressed by placental endothelial cells in women during early pregnancy would provide an insight into role of placental factors in virus transmission. Since viral spike protein binding to the ACE2 receptors of the host cells promotes virus invasion in placental tissue, an analysis of effects of Epap-1 on the Spike-ACE2 protein binding was studied.
View Article and Find Full Text PDFOxidative stress, imbalanced antioxidants, and dysregulated renal lipids are closely linked with diabetic nephropathy and eventual cause of end-stage renal failure. This study was performed to investigate the protective effect of bacoside-A on markers of lipid peroxidation, renal lipids, and markers of renal function in diabetic rats. Experimental diabetes was induced in Wistar rats by a single dose of streptozotocin [40 mg/kg body weight (BW)] via intraperitoneal injection.
View Article and Find Full Text PDFObjectives: The objectives of the current study was to evaluate the disinfection efficacy of ozone, ultraviolet (UV) radiation, herbal and glutaraldehyde method for sterilization of elastomeric impression materials.
Materials And Methods: Disinfection of elastomeric impression material was performed with each of the disinfection methods: ozone, UV radiation, herbal, and glutaraldehyde. Later microbiological analysis was performed and the colony-forming units were evaluated and compared.