[The influence of the peptide bioregulator prostamax on heterochromatin of human lymphocytes in situ].

It was shown that chromatin contained in human lymphocytes has two stages of denaturation: with T(d)VII = 94.4 degrees C, Q(d)VII = 50.8 J/g DNA, and T(d)VIII = 105.

[Microcalorimetric study of native cells of the microalgae Spirulina platensis in the temperature range (2-55)C].

Thermal effects occurring upon heating a culture of blue-green microalgae Spirulina platensis in the temperature range 5-55 degrees C were studied. Under these conditions, an intensive heat evolution was observed. The heat evolution-versus-temperature curve has a peak with a maximum at approximately 45 degrees C and two distinct shoulders at approximately 25 and 40 degrees C.

[Features of the process of chromatin denaturation in leukemic tissue and murine spleen cells].

It was shown by the method of differential scanning microcalorimetry that an additional peak, at about 57 degrees C appears on heat absorption curves of the whole spleen tissue and cells of BalB/c mouse injected with Rausher virus. It is supposed that this peak is due to the melting of AT-rich regions of internucleosomal DNA in chromatin fibers of tumor cells, which results from the partial loss of proteins or the modification of H1 histone.

[Thermal properties of chromatin in vivo during interaction with cis[Pt(CuO)2(CuOH)2]].

Thermal properties of chromatin in cell composition of BALB/c mice and whole chromatin at injection of cis-Pt(CuO)2(CuOH)2 to experimental animals were studied by high sensitive DSM assigning for investigating complex biological systems. It is established that injection of cis-Pt(CuO)2(CuOH)2 to leukemic mice in vivo changes the thermal characteristics of spleen cells, so that they look like the thermal properties of the healthy mice spleen cells. It was supposed that small doses of Pt(CuO)2(CuOH)2 in the case of leukemia show anticarcinogenic properties and the overdoses promote malignization; in the norm at any concentration of the injected salt cancerogenic properties are exhibited.

[Calorimetry of chromatin and DNA from ascitic cells of C3HA mice in the presence of copper ions].

The process of chromatin denaturation in the composition of C3HA line mice ascites cells was investigated by the method of scanning microcalorimetry. It is shown that copper ions injected into ascites tumour are inculcated in DNA double helix and injure it, and this caused disorder of high ordered chromatin structure.