Early initiation of ceftaroline-based combination therapy for methicillin-resistant Staphylococcus aureus bacteremia.

Purpose: Monotherapy with vancomycin or daptomycin remains guideline-based care for methicillin-resistant Staphylococcus aureus bacteremia (MRSA-B) despite concerns regarding efficacy. Limited data support potential benefit of combination therapy with ceftaroline as initial therapy. We present an assessment of outcomes of patients initiated on early combination therapy for MRSA-B.

Anti-Interleukin-23 Treatment Linked to Improved Infection Survival.

is a leading cause of healthcare associated infection and an unacceptably high proportion of patients with infection die despite conventional antibiotic treatment. Host-directed immunotherapy has been proposed as an ideal treatment modality for infection to mitigate the underlying toxin-mediated pathogenic immune response while sparing protective gut microbes. Interleukin-23 monoclonal antibody inhibitors are used extensively to control pro-inflammatory Th17 immune pathways in psoriasis and inflammatory bowel disease that are similarly important during infection.

Using sign tracking to experimentally increase self-control in rats.

Impulsive choice describes a preference for a smaller-sooner reward (SSR) over a larger-later reward (LLR). A large body of research has examined different procedures for decreasing impulsive choice in nonhuman subjects. One limitation of these procedures is the extensive training duration required to achieve the desired results.

Validation of a novel effort-discounting assessment and evaluation of the effort-delay confound on effort discounting.

A vast literature highlights the prevalence of impulsive decision making in maladaptive outcomes. Most research has focused on one form-delay discounting. Less research has focused on effort discounting, possibly because of a lack of a standardized task for assessment.