Publications by authors named "G Macedo"
is a plant widely cultivated for food and medicinal purposes. species have been reported as anti-inflammatory, antibacterial, anxiolytic, and antinephritic agents. This study aimed to evaluate the anti-inflammatory potential of the ethanolic extract (EE) from the aerial parts of and its most promising fraction in models of acute and chronic inflammation, including a psoriasis-like mouse model.
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- Capsule endoscopy (CE) is a minimally invasive procedure used to examine the gastrointestinal tract, but it can be time-consuming and has limited diagnostic effectiveness in the upper GI tract.
- Researchers developed an artificial intelligence (AI) model using convolutional neural networks (CNN) to automatically detect various types of pleomorphic lesions from a large dataset of CE images, evaluating its performance against expert classifications.
- The AI model demonstrated high diagnostic accuracy across different areas of the GI tract, with the best results being 96.6% accuracy for gastric lesions and 97.6% for small bowel lesions, suggesting that AI tools could significantly enhance the effectiveness of capsule panendoscopy.
Non-Invasive versus Invasive Assessment of Portal Hypertension in Chronic Liver Disease.
GE Port J Gastroenterol
December 2024
Background: Cirrhosis is one of the major causes of morbidity and mortality worldwide and the second leading cause of digestive disease mortality. Portal hypertension is the main driver of cirrhosis-related complications such as ascites and variceal bleeding. Portal hypertension is defined as a hepatic venous pressure gradient >5 mm Hg, although it is clinically significant and associated with clinical complications when >10 mm Hg.
View Article and Find Full Text PDFDexamethasone-loaded chitosan-decorated PLGA nanoparticles: A step forward in attenuating the COVID-19 cytokine storm?
Colloids Surf B Biointerfaces
February 2025
This study aims to develop and characterize poly (lactic-co-glycolic acid) (PLGA) nanoparticles decorated with chitosan (CS) for the encapsulation of dexamethasone (DEX) (NP-DEX-CS), targeting improved efficacy in the treatment of severe acute respiratory syndrome (SARS) associated with COVID-19. The nanoparticles were systematically characterized for size, zeta potential (ZP), morphology, encapsulation efficiency, and in vitro drug release. Incorporation of CS resulted in significant modifications in the nanoparticles' physical properties, notably an increase in size (from 207.
View Article and Find Full Text PDFBio-Guided Extraction of a Phenolic-Rich Extract from Industrial Peanut Skin with Antioxidant and Hypotensive Potential.
Foods
October 2024
Peanut composition includes phenolic compounds, especially in the skins, which are often not consumed. High blood pressure affects more than one billion people worldwide and is considered a high-risk factor for cardiovascular diseases. Several studies have correlated antihypertensive activity with the total phenolic content present in the plants.
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