SARS-CoV-2 can spread by close contact through large droplet spray and indirect contact via contaminated objects. There is mounting evidence that it can also be transmitted by inhalation of infected saliva aerosol particles. These particles are generated when breathing, talking, laughing, coughing or sneezing.
View Article and Find Full Text PDFObjective: To describe clinical characteristics of patients after intensive care unit (ICU) treatment for coronavirus disease 2019 (COVID-19) who were admitted for inpatient rehabilitation.
Design: A cross-sectional design.
Setting: Inpatient rehabilitation care in the Netherlands.
3-Aryl-1-(trifluoromethyl)prop-2-yn-1-iminium triflate salts represent a novel, highly reactive class of acetylenic iminium salts. Herein we present several reactions which are based on the electron-poor acetylenic bond and on the high electrophilicity of the CF-substituted iminium group. These salts were found to be highly reactive dienophiles in Diels-Alder reactions with cyclopentadiene, 2,3-dimethylbutadiene and even anthracene.
View Article and Find Full Text PDFBeilstein J Org Chem
November 2019
-Phenyl--(trifluoromethylsulfonyl)propiolamides react with triphenylphosphane in the presence of various active methylene compounds CHXY in a 1:1:1 molar ratio to furnish 1-phosphonium-5-oxabetaines, PhP-C(R)=CH-C(O)=CXY. These betaines are formed preferentially, but not exclusively, as -diastereoisomers with respect to the vinylic double bond. In some cases, separation of the two diastereoisomers was achieved by fractionating crystallization.
View Article and Find Full Text PDFObjective: To optimize rapid clinical recovery and restoration of function and functionality, permissive weight-bearing has been designed as a new aftercare mobilization regimen, within the upper boundary of the therapeutic bandwidth, yet safe enough to avoid overloading. The aim of the present paper is to describe a comprehensive protocol for permissive weight-bearing during allied health therapy and to report on the time to full weight-bearing, as well as the number of complications, in patients with surgically treated fractures of the pelvis and lower extremities undergoing permissive weight-bearing.
Patients And Methods: This study included surgically treated trauma patients with (peri)- or intra-articular fractures of the pelvis and lower extremities.