Publications by authors named "G MARX"
Introduction: Alzheimer's disease (AD), primary age-related tauopathy (PART), and chronic traumatic encephalopathy (CTE) all feature hyperphosphorylated tau (p-tau)-immunoreactive neurofibrillary degeneration, but differ in neuroanatomical distribution and progression of neurofibrillary degeneration and amyloid beta (Aβ) deposition.
Methods: We used Nanostring GeoMx Digital Spatial Profiling to compare the expression of 70 proteins in neurofibrillary tangle (NFT)-bearing and non-NFT-bearing neurons in hippocampal CA1, CA2, and CA4 subregions and entorhinal cortex of cases with autopsy-confirmed AD (n = 8), PART (n = 7), and CTE (n = 5).
Results: There were numerous subregion-specific differences related to Aβ processing, autophagy/proteostasis, inflammation, gliosis, oxidative stress, neuronal/synaptic integrity, and p-tau epitopes among these different disorders.
Background: Patients with advanced chronic non-malignant conditions often experience significant symptom burden. Therefore, overcoming barriers to interprofessional collaboration between general practitioners (GPs) and specialist palliative home care (SPHC) teams is essential to facilitate the timely integration of palliative care elements. The KOPAL trial aimed to examine the impact of case conferences between GPs and SPHC teams on symptom burden and pain in patients with advanced chronic heart failure, chronic obstructive pulmonary disease, and dementia.
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- - A survey of US infectious disease specialists found that 61 reported cases of Bartonella quintana infections from 2014 to 2024.
- - Key challenges in diagnosing these infections are a lack of awareness among healthcare providers, insufficient testing, and uneven access to healthcare for affected groups.
- - To enhance patient outcomes, it's crucial to improve early recognition of B. quintana infections.
Article Synopsis
- - Bartonella quintana can lead to serious health issues, including endocarditis and chronic infections, and is mainly spread by body lice, particularly in homeless populations.
- - A case study in the U.S. highlighted two kidney transplant recipients who contracted the infection from an organ donor who was homeless; one case was atypical while the other showed mild symptoms.
- - Timely detection and treatment allowed both recipients to recover, emphasizing the importance of assessing organ donors' living conditions, specifically those with a history of homelessness or lice infestations, for potential B. quintana infections in transplant recipients.
Article Synopsis
- Bartonella quintana infection can cause serious health issues like bacillary angiomatosis and culture-negative endocarditis, mainly affecting individuals who are homeless.
- In a study conducted in New York City between January 2020 and November 2023, five cases of left-sided, culture-negative endocarditis were identified in unsheltered homeless persons using molecular methods.
- Most patients had serious complications and a history of body louse exposure, highlighting the need for clinicians to consider housing status and potential lice infestation when diagnosing and treating suspected cases.