CMV plasma DNAemia and risk of cancer among HIV-infected patients: a case-control study nested in the ANRS CO3 Aquitaine Cohort, France, 2002-2007.

Background: CMV reactivation, which enhances immune senescence, could be associated with a higher risk of cancer.

Objectives: We compared the prevalence of positive CMV DNAemia in HIV-infected patients with and without cancer.

Study Design: This case-control study, nested in the ANRS-CO3 Aquitaine Cohort, included patients with a first diagnosis of cancer (2002-2007) as cases.

Two novel plant cDNAs homologous to animal type-2 phosphatidate phosphatase are expressed in cowpea leaves and are differently regulated by water deficits.

Two cDNAs encoding putative phosphatidate phosphatases (PAPs) designated VuPAP-alpha and VuPAP-beta were cloned in cowpea (Vigna unguiculata L.) leaves. The predicted proteins have six membrane-spanning regions in common with animal type-2 PAPs.

Binding of two anthranilic acid derivatives to human albumin, erythrocytes, and lipoproteins: evidence for glafenic acid high affinity binding.

The binding of two anthranilic acid derivatives, glafenic and floctafenic acids, to human erythrocytes and plasma proteins has been investigated in vitro by equilibrium dialysis. Despite their close chemical structures it was shown that the binding of the two compounds to serum albumin, lipoproteins, and erythrocytes was dramatically different both in quality and quantity. Using various techniques including fluorometry and circular dichroism, it was shown that glafenic acid binds to the human serum albumin (HSA) warfarin/azapropazone site and that floctafenic acid binds to both warfarin/azapropazone and benzodiazepine sites.

Assessment of erythrocyte deformability by constant flow filtration technique: analysis of factors influencing the initial pressure.

When filtering red blood cells (RBC) resuspended into buffer at constant flow, the pressure-time curve is dependent on erythrocyte deformability (E.D) and also on the plugging of pores by RBC or leukocytes (WBC). To understand the influence of these 3 factors, we used an apparatus with: 1) a constant flow syringe (Bioblock) (1.