Publications by authors named "G M Varghese"
Ralstonia species are recently emerging as pathogens of human importance. This study was performed to assess the distribution of Ralstonia species among bacteremia patients and the clinical and demographical factors of these patients. This retrospective observational study was performed in the Microbiology Department of a tertiary care center in North India from April 2022 to April 2024.
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- Trauma and accidental injuries are a major global health concern, with India experiencing the highest road accident deaths, accounting for 11% of the world's total.
- A study from January 2023 to January 2024 analyzed wound samples from road traffic accident (RTA) patients in a northern Indian tertiary care center to assess bacterial contamination and antibiotic susceptibility.
- Out of 189 samples, 52.38% showed microbial growth, predominantly Gram-negative bacilli, with none being resistant to colistin; 26.45% of patients developed sepsis, linked to raised procalcitonin levels and low Glasgow Coma Scale scores.
Introduction: International guidelines recommend definitive combination antibiotic therapy for the management of serious infections involving carbapenem-resistant Acinetobacter (CRAB) species. The commonly available combination options include high-dose sulbactam, polymyxins, tetracyclines, and cefiderocol. Scanty prospective data exist to support this approach.
View Article and Find Full Text PDFBackground: Scrub typhus, caused by Orientia tsutsugamushi involves infiltration of a mixture of perivascular lymphocytes and macrophages into affected organs. We investigated if this is characterized by chemokine dysregulation.
Methods: mRNA expression of chemokines and receptors were screened in whole blood by cDNA microarray in a subgroup of patients and controls.
Article Synopsis
- The study focused on gram-negative bacteremia (GNB) in cancer patients, looking at characteristics, outcomes, and risk factors for multi-drug-resistant (MDR) GNB.
- Researchers analyzed data from 1,074 patients admitted in 2022, finding that almost half of GNB cases were MDR and linked previous antibiotic use to higher MDR risk.
- The results showed that MDR-GNB led to longer hospital stays and greater recurrence of infections but did not significantly increase 30-day mortality compared to non-MDR cases.