Publications by authors named "G M Turino"
The relationship between elastin cross linking and alveolar wall rupture in human pulmonary emphysema.
Am J Physiol Lung Cell Mol Physiol
June 2023
Article Synopsis
- The study explores the role of mechanical forces in pulmonary emphysema by examining the relationship between airspace size and elastin-specific biomarkers (DID) in human lungs.* -
- Results showed that larger airspaces (over 400 µm) are associated with increased elastin breakdown and higher levels of DID, indicating a response to alveolar wall distention.* -
- The findings suggest a two-phase process where initial elastin cross-linking occurs to counteract lung damage, followed by a rapid decline in elastin as the disease progresses, making treatment more difficult.*
Background: Prolonged past exposure to secondhand tobacco smoke (SHS) in never-smokers is associated with abnormal lung function and reduced diffusing capacity suggestive of an associated lung tissue injury and damage. The mechanisms by which past SHS exposure may contribute to lung tissue damage are unknown. Elastin is a major constituent of extracellular matrix in lung parenchyma.
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- - A 28-day trial tested the effects of aerosolized hyaluronan (HA) on individuals with COPD caused by alpha-1 antiprotease deficiency, building on earlier findings of reduced lung damage markers after a shorter trial.
- - Participants self-administered a solution of HA, with researchers measuring levels of desmosine and isodesmosine (DID) in urine, sputum, and plasma to assess lung health.
- - Results showed a significant decrease in urine DID levels in the HA group, suggesting it could be a marker for monitoring treatment effects, reinforcing the need for more extensive clinical trials.
The Proinflammatory Activity of Structurally Altered Elastic Fibers.
Am J Respir Cell Mol Biol
November 2020
The mechanisms responsible for the increased loss of pulmonary function following acute lung inflammation in chronic obstructive pulmonary disease remain poorly understood. To investigate this process, our laboratory developed a hamster model that uses a single intratracheal instillation of LPS to superimpose an inflammatory response on lungs treated with intratracheal elastase 1 week earlier. Parameters measured at 2 days after LPS included total leukocyte content and percent neutrophils in BAL fluid (BALF), and BALF levels of both total and peptide-free elastin-specific crosslinks, desmosine and isodesmosine (DID).
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