Publications by authors named "G M Shanab"
Article Synopsis
- - Bithiophene derivatives, like Bithienyl Fluorobenzamidine (BFB), show potential as anti-cancer agents, particularly against acute myeloid leukemia (AML), which is a significant health issue globally.
- - The study examined how BFB affects cancer cell growth and triggers cell death (apoptosis) in mice with DMBA-induced AML, utilizing various scientific methods to assess changes in blood cells and tissue.
- - Results demonstrated that BFB notably improves leukemia-related symptoms and promotes apoptosis and cell cycle arrest in leukemia cells, positioning it as a potential treatment for AML through modulation of specific cellular pathways.
We applied, for the first time, next-generation sequencing (NGS) technology on Egyptian mummies. Seven NGS datasets obtained from five randomly selected Third Intermediate to Graeco-Roman Egyptian mummies (806 BC-124AD) and two unearthed pre-contact Bolivian lowland skeletons were generated and characterised. The datasets were contrasted to three recently published NGS datasets obtained from cold-climate regions, i.
View Article and Find Full Text PDFIn the present study, we examined the effects of free fatty acids (FFAs) on insulin sensitivity and signaling cascades in the C2C12 skeletal muscle cell culture system. Our data clearly manifested that the inhibitory effects of PKC on insulin signaling may at least in part be explained by the serine/threonine phosphorylation of IRS-1. Both oleate and palmitate treatment were able to increase the Serine(307) phosphorylation of IRS-1.
View Article and Find Full Text PDFIn the current study, we show evidence, in a fructose-fed hamster model of insulin resistance, that free fatty acid (FFA) can induce hepatic insulin resistance in part via PKC activation leading to increased production of atherogenic apoB100-containing lipoproteins. Interestingly, IkappaB-kinase beta (IKKbeta)-dependent NF-kappaB was activated in hepatocytes from the fructose-fed hamster as an indication for PKC activation. Treatment of hepatocytes with oleate for 16h showed the activation of the PKC isoforms, PKCalpha/betaII, in a dose dependent manner.
View Article and Find Full Text PDFObjectives: The aim of this study is to provide preliminary molecular data on spinal muscular atrophy in Egyptian patients thus facilitating a rapid and conventional molecular assay for accurate diagnosis of SMA.
Background: Childhood spinal muscular atrophy (SMA) is one of the most common autosomal recessive disorders. It is characterized by symmetrical muscle weakness and atrophy of limbs and trunk.