Publications by authors named "G M Shackleford"
Article Synopsis
- Myelin is key for fast nerve signaling and protecting axons; defects in myelin can lead to further axonal damage and degeneration.* -
- Mutations in the Myelin Protein Zero (P0) gene are linked to demyelinating neuropathies, with the P0T124M mutation causing axonal neuropathy (CMT2J) without significant myelin damage, offering insight into how myelin-supporting cells can influence axons independently.* -
- Research on MpzT124M mutant mice reveals that Schwann cells struggle to support axons properly, leading to metabolic changes, axonal degeneration, and impaired motor function, mimicking symptoms seen in patients with CMT2J.*
MYC family oncoproteins MYC, MYCN, and MYCL are deregulated in diverse cancers and via diverse mechanisms. Recent studies established a novel form of MYCN regulation in MYCN-overexpressing retinoblastoma and neuroblastoma cells in which the MDM2 oncoprotein promotes MYCN translation and MYCN-dependent proliferation via a p53-independent mechanism. However, it is unclear if MDM2 also promotes expression of other MYC family members and has similar effects in other cancers.
View Article and Find Full Text PDFG-protein coupled receptor kinase 2 (GRK2; ADRBK1, BARK1) is most known as a regulator of G-protein coupled receptors. However, GRK2 also has other functions. Medulloblastomas are the most common malignant brain cancers in children.
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