Publications by authors named "G M Sare"
Background: Clinical diagnosis and monitoring of Parkinson's disease (PD) remain challenging because of the lack of an established biomarker. Neuromelanin-magnetic resonance imaging (NM-MRI) is an emerging biomarker of nigral depigmentation indexing the loss of melanized neurons but has unknown prospective diagnostic and tracking performance in multicenter settings.
Objectives: The aim was to investigate the diagnostic accuracy of NM-MRI in early PD in a multiprotocol setting and to determine and compare serial NM-MRI changes in PD and controls.
Article Synopsis
- The study investigates how lowering blood pressure in stroke patients with carotid stenosis affects their recovery, specifically looking at the use of glyceryl trinitrate (GTN) from the ENOS Trial data.
- Results indicate that severe ipsilateral carotid stenosis leads to poorer functional outcomes at 90 days post-stroke; however, administering GTN may improve these outcomes in patients with severe stenosis.
- Additionally, for patients with 50-<70% stenosis, continuing antihypertensive treatment was linked to worse overall health outcomes, while clinical outcomes showed no significant differences in groups with bilateral stenosis.
Introduction: Parkinson's disease (PD) is the most common movement disorder in the elderly and is characterised clinically by bradykinesia, tremor and rigidity. Diagnosing Parkinson's can be difficult especially in the early stages. High-resolution nigrosome MRI offers promising diagnostic accuracy of patients with established clinical symptoms; however, it is unclear whether this may help to establish the diagnosis in the early stages of PD, when there is diagnostic uncertainty.
View Article and Find Full Text PDFBackground: Poststroke cognitive impairment is common and identification of prognostic factors associated with it and its relationship with other functional outcomes may help in developing preventative strategies.
Methods: Previously independent patients with acute stroke, enrolled into the ongoing "Efficacy of Nitric Oxide in Stroke" trial, were assessed by telephone on day 90 for cognitive impairment using modified versions of "Mini Mental State Examination" (MMSE-M) and "Telephone Instrument for Cognitive Status" (TICS-M) scales and category fluency. The relationship of cognitive impairment with baseline prognostic factors and other functional outcomes at day 90 were studied.