Publications by authors named "G M Sancesario"
Phosphodiesterase 2 A (PDE2A) function is stimulated by cGMP to catabolize cAMP. However, neurological and neurochemical effects of PDE2A deficiency are poorly understood. To address this gap, we studied behavioral characteristics and cerebral morpho-chemical changes of adult male heterozygous C57BL/6-PDE2A+/- (HET), and wild type C57BL/6-PDE2A+/+ (WT) mice.
View Article and Find Full Text PDFBackground: Gastrointestinal dysfunction (GID) accompanies any phase of Parkinson's disease (PD), underlying differential clinical-pathological trajectories.
Objective: To investigate associations between GID and peripheral immune or neurodegeneration-related markers in PD.
Methods: One-hundred-and-fourteen patients (n = 55 de novo, DN; n = 59 middle-advanced, MA) completed the Gastrointestinal Dysfunction Scale for PD (GIDS-PD), and other motor and non-motor scales; paired measurement of amyloid-β42, amyloid-β42β/β40, total-tau, phosphorylated-181-tau, total α-synuclein CSF levels, albumin ratio, and peripheral blood cell count were collected.
Article Synopsis
- - ApoE is a glycoprotein critical for lipid transport and metabolism, with the E4 allele being a known risk factor for Alzheimer's disease and potentially other neurological disorders like Parkinson's disease and brain trauma.
- - Recent findings suggest that the E4 allele is linked to worse clinical outcomes in various neurological conditions, mainly through its role in processes like amyloid-β accumulation and neuroinflammation.
- - This review aims to summarize the role of ApoE in neurodegenerative diseases and discuss the ethical considerations surrounding genetic testing for APOE variants, emphasizing its clinical significance.
Biobanking, digital health and privacy: the choices of 1410 volunteers and neurological patients regarding limitations on use of data and biological samples, return of results and sharing.
BMC Med Ethics
September 2024
Article Synopsis
- The text discusses the ethical and legal considerations surrounding the collection of biological samples and data for research, especially in the context of neurological diseases and the role of biobanking.
- A study evaluated attitudes towards donating samples for biobanks among 1,454 participants, including healthy volunteers and patients with neurological conditions, with a high level of agreement on participation in biobanking.
- Key findings show significant differences in preferences regarding the return of results and data sharing, notably that healthy volunteers were more likely to want to remain uninformed about results compared to patients.
β-amyloid (Aβ) in Alzheimer's disease (AD) and orexin in narcolepsy are considered crucial biomarkers for diagnosis and therapeutic targets. Recently, orexin and Aβ cerebral dynamics have been studied in both pathologies, but how they interact with each other remains further to be known. In this study, we investigated the reliability of using the correlation between orexin-A and Aβ CSF levels as a candidate marker to explain the chain of events leading to narcolepsy or AD pathology.
View Article and Find Full Text PDF