Assessing the economic impact and healthcare resource utilization of inpatient pneumococcal disease among adults: a French national claims database study.

Introduction: Pneumococcal diseases (PD) caused by include invasive PD (IPD) and non-bacteremia pneumococcal pneumonia (NBPP). Current French vaccination guidelines FOCUS on patients with underlying medical conditions (UMC) who are at a higher risk of PD. This study describes the healthcare resource utilization (HCRU) and economic burden of inpatient PD in French adults, to inform vaccination guidelines, especially among vulnerable subpopulations at increased risk of PD.

Dynamics of Pyrene Excimer in a Cholesteryl-based Supramolecular Host Matrix.

Aggregation-caused quenching (ACQ) reduces luminescence and compromises brightness in solid-state displays, necessitating strategies to mitigate its effects for enhanced performance. This study presents cost-effective method to mitigate ACQ of pyrene by co-assembling polycyclic aromatic hydrocarbons within low molecular weight gelator. ​Synthesized from readily available materials-cholesteryl chloroformate and pentaerythritol-in one-step reaction, gelator incorporates four cholesteryl units, reported to promote robust supramolecular gels in various solvents.

Target deconvolution of an insulin hypersecretion-inducer acting through VDAC1 with a distinct transcriptomic signature in beta-cells.

Obesity, insulin resistance, and a host of environmental and genetic factors can drive hyperglycemia, causing β-cells to compensate by increasing insulin production and secretion. In type 2 diabetes (T2D), β-cells under these conditions eventually fail. Rare β-cell diseases like congenital hyperinsulinism (HI) also cause inappropriate insulin secretion, and some HI patients develop diabetes.

Sustainable Synthesis of Nitrogen-Embedded CuS Quantum Dots for In Vitro and In Vivo Breast Cancer Management.

The burgeoning field of nanomedicine is exploring quantum dots for cancer theranostics. In recent years, chemically engineered copper sulfide (CuS) quantum dots (QDs) have emerged as a multifunctional platform for fluorescence-based sensors with prominent applications in imaging and chemodynamic therapy of tumor cells. The present study demonstrates the sustainable synthesis of nitrogen-embedded copper sulfide (N@CuS) quantum dots for the first time and unveils their potential application in in vitro and in vivo breast cancer management.

Identification of novel inhibitors from as anti-leishmanial agents targeting DDX3-DEAD box RNA helicase of .

Unlabelled: Visceral leishmaniasis (VL), caused by , remains challenging to treat due to severe side effects and increasing drug resistance associated with current chemotherapies. Our study investigates the anti-leishmanial potential of from Uttarakhand, India, with extracts prepared from leaves and stems using ethanol and hexane. Advanced GC-MS analysis identified over 100 bioactive compounds, which were screened using molecular docking to assess their binding to LdHEL-67, a DDX3-DEAD box RNA helicase of donovani.