[Analysis of the antigenic specificity of cell subpopulations of Ehrlich ascites cancer].

Antigenic differences between primary peridiploid Ehrlich tumour and subpopulations of tumour cells obtained from it on the 35th or 185th day of their growth were studied by the method of transplantation resistance. The development of peridiploid tumour in mice immunized with the peritetraploid subpopulation of cells and that of peritetraploid tumours in mice immunized with peridiploid subpopulation of cells evidences for alterations in specificity of antigenic tumour with an increase or decrease in its ploidy. Antigenic differences between karyotypically distinguishing subpopulations isolated from different tumour regions were revealed.

[Karyotypic variability of a tumor cell population in the process of prolonged growth in the body].

An ascite variant of spontaneous mammary gland tumor of C3H/Sn mice was transplanted subcutaneously into syngenic mice. During the tumor growth (150 days) some alterations occur in the genetical structure of the tumor population: a change in the stem line, the increase and a further decrease of nearoctaploid cells.