Dimethylarginines and serotonin in the blood of spontaneously hypertensive rats.

The serotoninergic system and nitric oxide system were studied in spontaneously hypertensive rats SHR and Wistar rats (control). The contents of serotonin, 5-hydroxyindoleacetic acid (serotonin metabolite), L-arginine, monomethylarginine, and asymmetric and symmetric dimethylarginines were measured in blood plasma. Serotonin content in hypertensive animals was much higher than in Wistar rats.

Hypothalamic monoamines in cold stress on the background of changes in the activity of the nitric oxide system.

The effects of the NO donor sodium nitroprusside and the NO synthase blocker L-omega-N-nitroarginine (LNA) on body temperature, hypothalamic monoamines, and plasma corticosterone in conditions of cooling were studied in Male Wistar rats. Reductions in body temperature on cooling, both after administration of sodium nitroprusside and LNA, were no different from those seen without treatment. The basal corticosterone level after treatment with sodium nitroprusside increased from 5.

[Hypothalamic monoamines in the cold stress during changes in activity of nitric oxide system].

Effects of NO-synthase inhibitor N(omega)-nitro-L-arginine (LNA) and donor sodium nitroprusside (SNP) on alteration in body temperature, plasma corticosterone level and hypothalamic monoamines in response to cold exposure, were studied. Drop of the body temperature in cold exposure in rats treated with LNA or SNP was the same as in the control group. Administration of SNP (2 mg/kg i.

[Effect of haloperidol on transmembrane potential and viscosity of thymocyte membrane lipids].

A damaging effect of the neuroleptic haloperidol on thymocytes was studied in vivo. The integral state of energetic processes in the cells was described by the electric transmembrane potential of thymocytes delta psi equal to the sum of potential on the plasmic and mitochondrial membranes. The effect of haloperidol was also evaluated by the content of lipid peroxidation (LPO) products and by the structural and functional characteristics of thymocyte membranes (lipid viscosity, protein-lipid interaction).