MXene-rGO nanocomposite based electrochemical immunosensor for detection of endosulfan - An organochlorine pesticide.

Endosulfan (Ed), a widely used organochlorine pesticide, is classified as a persistent organic pollutant (POP). Its long half-life, resistance to degradation, and bioaccumulation in the food chain contaminates soil, water, and air. Such widespread environmental damage triggers monitoring its levels for ensuring compliance with safety regulations and protecting public health.

Mechanistic Modeling the Role of MicroRNAs and Transcription Factors in Disease Progression.

In this chapter, we illustrate the utilization of network analysis and mechanistic modeling, two potent branches of systems biology, to simplify the representation of intricate biological processes such as cell signaling, gene regulation, and metabolic pathways. Specifically, we demonstrate the application of a well-established method to generate a microRNA-transcription factor-gene regulatory feed-forward loop network extracted from the GEO dataset GSE163877. Furthermore, we outline a method for constructing a deterministic model using the LSODA method based on the sub-network.

Oesophageal pulmonary fistula secondary to oesophageal carcinoma.

A man in his early 60s presented with dysphagia and odynophagia. He was diagnosed with squamous cell carcinoma of the oesophagus. During his hospital stay, he developed a productive cough and experienced recurrent fever spikes.