Immunomodulators in the prevention of acute respiratory viral infections.

The polyethiology of the respiratory diseases and the lack of effective vaccines to prevent them (except for influenza) underline the need for clinical trials and the practical application of immunomodulatory preparations that could become part of the group of anti-viral drugs with a wide range of activity. It has been demonstrated that amixin and poludan, the drugs made in our country, cause an increase of the serum IFN level, enhance the ability of leukocytes and lymphocytes to produce IFN-alpha and IFN-gamma, and lead to the activation of NK and peripheral blood phagocytes. In other words, they have an immunostimulating activity.

[Evaluation of amixine reactivity and efficacy for prophylaxis of acute respiratory tract infections].

Amixine reactivity and tolerability were evaluated in controlled trial at the risk group of medical personal at the period of flu and respiratory viral infection season. Drugs safety was estimated according to anamnesis, direct observation and hemogram. High efficacy of the drug for the infections prophylaxis and treatment was demonstrated.

[Computed image analysis of neutrophils: alkaline phosphatase].

Alkaline phosphatase (AP) activity was detected under optic microscope in neutrophilic leukocyte granules and intergranular cytoplasm. Computer analysis of the image showed that activation of neutrophils in the blood of patients with purulent peritonitis was paralleled by a drastic increase in the activity of AP and its intracellular redistribution. AP granules increased in size and their capacity to conglomeration increased.

[Evaluation of amyxin effect in prophylaxis of acute respiratory viral infections].

The results of the evaluation of the oral inductor of endogenic interferon (amyxin), manufactured in Russia are presented. The use of amyxin was found to produce a drop in morbidity in acute respiratory virus infections (ARVI) among medical workers 3.4 times, i.

[[Computed imaging analysis of neutrophils: myeloperoxidase]lysis of].

Computer analysis of the cell image showed granular and diffuse activities of myeloperoxidase (MP) in the neutrophil cytoplasm. MP in the intergranular cytoplasm can be regarded as a product of secretory activity of azurophilic granules. The patterns of MP distribution in the neutrophils of normal subjects and patients with peritonitis are different.