Publications by authors named "G M Loos"
Purpose: Brachytherapy as monotherapy is a recommended treatment option for men with low to intermediate risk prostate cancer. Local recurrence is difficult to identify. This study investigated PSMA PET/CT for recurrence after brachytherapy, as well as their subsequent management when recurrence occurred only within the prostate.
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- Androgen deprivation therapy (ADT) combined with elective nodal radiotherapy (ENRT) shows promising long-term outcomes for men with limited prostate cancer recurrence, specifically targeting pelvic lymph nodes.
- In a trial involving 67 patients, after a median follow-up of over 6 years, a significant proportion experienced prolonged tumor control with manageable levels of toxicities.
- After 5 years, about one-third of patients remained free from biochemical relapse, highlighting ENRT's effectiveness in maintaining remission and delaying disease progression.
Article Synopsis
- The study investigates the effectiveness and safety of stereotactic body radiation therapy (SBRT) as a salvage treatment for prostate cancer recurrence after previous radiation therapy, focusing on determining the best dosing regimen.
- It included 21 patients with specific cancer characteristics, delivering either five or six doses of 6 Gy, and monitored for any severe side effects in the first 18 weeks post-treatment.
- Results showed no severe complications, and while some patients experienced mild genitourinary issues, all were alive and cancer-free during the follow-up, leading to a recommendation for the 6 × 6 Gy dosage to advance further studies.
Purpose: To assess the diagnostic precision of three different workstations for measuring thoracic aortic aneurysms (TAAs) in vivo and ex vivo using either pre-interventional computed tomography angiography scans (CTA) or a specifically designed phantom model.
Methods: This retrospective study included 23 patients with confirmed TAA on routinely performed CTAs. In addition to phantom tube diameters, one experienced blinded radiologist evaluated the dimensions of TAAs on three different workstations in two separate rounds.
Article Synopsis
- The study investigates the effectiveness of combining androgen deprivation therapy (ADT) with high-dose salvage radiotherapy in men with oligorecurrent pelvic node relapses of prostate cancer, aiming to extend the period without cancer progression.
- Conducted as an open-label phase II trial with 67 participants over a median follow-up of about 49 months, the results indicate strong progression-free survival rates of 81% at 2 years and 58% at 3 years, with manageable side effects reported.
- The findings suggest that this combination treatment can lead to prolonged tumor control and remission in nearly half of the patients after 3 years, indicating a promising approach for managing this challenging cancer recurrence scenario.