Event-related potentials and presaccadic activity in response to affective stimuli in participants with obsessive-compulsive disorder.

Individuals with obsessive-compulsive disorder (OCD) have difficulty with regulating their emotions and show reduced functioning of inhibitory control. It was reported previously that OCD patients had delayed antisaccade response and increased error rate only when affective pictures with negative valence served as fixation stimuli in "the antisaccade emotional fixation task". Complementary to the previous research, eye movements and late positive potential (LPP) for fixation stimuli and the presaccadic positivity (PSP) and spike potential (SP) before saccade onset, were compared in two groups of OCD and healthy volunteers.

Key features of the innate immune response is mediated by the immunoproteasome in microglia.

Microglia are the resident immune cells of the central nervous system (CNS). We and others have shown that the inflammatory response of microglia is partially regulated by the immunoproteasome, an inducible form of the proteasome responsible for the generation of major histocompatibility complex (MHC) class I epitopes. While the role of the proteasome in the adaptive immune system is well established, emerging evidence suggests the immunoproteasome may have discrete functions in the innate immune response.

Comparative analysis of resting-state EEG functional connectivity in depression and obsessive-compulsive disorder.

Major depressive disorder (MDD) and obsessive-compulsive disorder (OCD) are psychiatric disorders that often co-occur. We aimed to investigate whether their high comorbidity could be traced not only by clinical manifestations, but also at the level of functional brain activity. In this paper, we examined the differences in functional connectivity (FC) at the whole-brain level and within the default mode network (DMN).

The Dynamics of Resting-State EEG and Salivary Trace Elements in Patients with Obsessive-Compulsive Disorder.

The study of salivary microelements and their neurophysiological and behavioral correlates in patients with obsessive-compulsive disorder (OCD) is a pressing issue in modern psychiatry, which, however, lacks adequate research at this time. In this study, we tested the dynamics of behavioral parameters, resting-state electroencephalogram (EEG), and salivary iron, copper, manganese, magnesium, and zinc in 30 healthy volunteers and 30 individuals with OCD before and after an emotional antisaccade task. The eye-movement data served as a measure of behavioral performance.

Long-range temporal correlations in resting state alpha oscillations in major depressive disorder and obsessive-compulsive disorder.

Introduction: Mental disorders are a significant concern in contemporary society, with a pressing need to identify biological markers. Long-range temporal correlations (LRTC) of brain rhythms have been widespread in clinical cohort studies, especially in major depressive disorder (MDD). However, research on LRTC in obsessive-compulsive disorder (OCD) is severely limited.