Publications by authors named "G M Hashiro"

Purpose: To prospectively evaluate serum and follicular fluid leptin, estradiol, and progesterone levels during in vitro fertilization.

Methods: Prospective observational study measuring serum levels at six points during the IVF cycle and follicular fluid at the time of retrieval.

Results: Serum leptin and estradiol levels both significantly increased for the individual patients during the IVF stimulation process.

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Objective: To evaluate the expression of Cox-2 protein by immunohistochemistry in cervical dysplasias, and to determine any relationship to clinical factors such as degree or recurrence of dysplasia.

Methods: Immunohistochemical expression of p27 and Cox-2 was initially examined in 62 cervical LEEP specimens, which spanned the histologic spectrum from benign to severe dysplasia. Histology and cytology from colposcopic follow-up exams were reviewed for 1 year after LEEP procedure.

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Despite evidence of surfactant dysfunction in the acute respiratory distress syndrome (ARDS), treatment with exogenous surfactant remains experimental. Uneven pulmonary distribution is one factor that may limit response. We investigated whether exogenous surfactant administered by lavage, consisting of a 35 ml/kg volume instilled by gravity and followed immediately by passive drainage (LAVAGE), would result in better lung distribution and physiologic response than with surfactant administered as a 5 ml/kg bolus (BOLUS).

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Objective: To determine the pulmonary function and hemodynamic effects of incremental positive end-expiratory pressure in two groups of normal ventilated newborn piglets with different baseline dynamic lung compliance.

Design: Prospective, controlled, intervention study.

Setting: Animal laboratory.

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