Publications by authors named "G M Donovan"
With the impending 'retirement' of bronchial thermoplasty (BT) for the treatment of patients with asthma, there is much to learn from this real-world experiment that will help us develop more effective future therapies with the same primary target i.e., airway smooth muscle (ASM) remodelling.
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- Early lung function deficits can begin in childhood and are linked to developmental issues, leading to long-term risks for diseases like asthma and COPD.
- Suboptimal fetal development, marked by low birth weight and intrauterine growth restriction, increases the likelihood of obstructive diseases later in life.
- Prenatal exposures affecting growth can cause various structural and physiological abnormalities, highlighting the importance of early interventions, such as nutrition or antioxidant therapy, to support healthy lung development.
The endoplasmic reticulum (ER) network is highly complex and highly dynamic in its geometry, and undergoes extensive remodeling and bulk flow. It is known that the ER dynamics are driven by actin-myosin dependent processes. ER motion through the cytoplasm will cause forces on the cytoplasm that will induce flow.
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