Allogeneic mesenchymal stem cells improve the wound healing process of sheep skin.

Background: Skin wound healing includes a system of biological processes, collectively restoring the integrity of the skin after injury. Healing by second intention refers to repair of large and deep wounds where the tissue edges cannot be approximated and substantial scarring is often observed. The objective of this study was to evaluate the effects of mesenchymal stem cells (MSCs) in second intention healing using a surgical wound model in sheep.

Handgrip strength among nonagenarians and centenarians in three European regions.

Background: Handgrip strength is an important predictor of disability and mortality among old people. The aim was to compare the grip strength among very old people in three regions of Europe.

Methods: In this substudy of the European Challenge for Healthy Aging project, only the long-lived probands were included.