An In Vitro Evaluation of Four Types of Drug-Eluting Embolics Loaded with Idarubicin.

Purpose: This study compared loading, elution, and stability of drug-eluting embolic beads (DEBs) loaded with idarubicin.

Materials And Methods: DC Bead (100-300 μm), HepaSphere (30-60 μm), LifePearl (200 μm), and Tandem (100 μm) DEBs were loaded with 5 mg/mL idarubicin. Loading, elution, diameter changes, loading stability over 2 weeks in storage, and time in suspension were determined for each of the DEBs.

New Interventional Treatment Model for Pancreatic Neoplasms Using Gemcitabine-Eluting Hydrogel Devices: In Vitro and In Vivo Results.

Objectives: In vitro and in vivo evaluation of fast- and slow-release gemcitabine-eluting hydrogel (GEH) devices.

Methods: For in vitro elution, the GEH devices were placed in phosphate-buffered saline at 37 °C. Periodically, the solution was analyzed for gemcitabine.

An in-vitro evaluation of three types of drug-eluting microspheres loaded with irinotecan.

To compare the mechanical and chemical properties of three commercially available microspheres loaded with irinotecan. LifePearl (200 µm), DC Bead (100-300 µm), and Tandem (100 µm) microspheres were loaded with irinotecan. For loading, elution, and stability determinations, irinotecan concentrations were quantified using validated high-performance liquid chromatography methods.

An In Vitro Evaluation of Four Types of Drug-Eluting Microspheres Loaded with Doxorubicin.

Purpose: To compare in vitro properties of 4 drug-eluting embolic agents loaded with doxorubicin.

Materials And Methods: DC Bead (100-300 µm), LifePearl (200 µm), HepaSphere (30-60 µm), and Tandem (100 µm) microspheres were loaded with 40 mg/20 mL of doxorubicin per milliliter of microspheres. Loading, elution, diameter changes after loading, changes in the amount of doxorubicin loaded over 2 weeks in storage, and time in suspension were evaluated.

Histological analysis of clipped human intracranial aneurysms and parent arteries with short-term follow-up.

Background: Surgical clipping of intracranial aneurysms is the gold standard for the prevention of rupture. However, the biological processes that occur following clipping are poorly understood. To better understand these effects, retrieved and clipped human intracranial aneurysms were examined histologically.