Detrimental effects of chronic sugar-sweetened carbonated soft drink consumption on inflammatory response and the size of apical periodontitis: An animal-based study.

Aim: This study aimed to evaluate the effects of chronic consumption of two sugar-sweetened carbonated soft drinks - one containing caffeine (Coca-Cola®) and one without (Sprite®) - on the progression of periapical lesions and the levels of pro-inflammatory cytokines in rats.

Methodology: Twelve Wistar rats were divided into three groups (n = 4): Control group, Coca-Cola group and Sprite group. The rats in Coca-Cola and Sprite groups were given ad libitum access to their respective soft drinks for 3 months, while the Control group received filtered water.

Sulfur fertilization and inoculation of soybean with Azospirillum brasilense and Bradyrhizobium spp. can improve grain yield and quality.

The success of biological nitrogen fixation (BNF) in soybean depends on two crucial factors, viz., seed inoculation and soil nutritional balance. The macronutrient sulfur (S) is vital to the formation of ferredoxin, a common source of electrons that controls the proper functioning of the subunits of the enzyme nitrogenase, responsible for the conversion of atmospheric nitrogen (N) to ammonia (NH).

Benzocarbazoledinones as SARS-CoV-2 Replication Inhibitors: Synthesis, Cell-Based Studies, Enzyme Inhibition, Molecular Modeling, and Pharmacokinetics Insights.

Endemic and pandemic viruses represent significant public health challenges, leading to substantial morbidity and mortality over time. The COVID-19 pandemic has underscored the urgent need for the development and discovery of new, potent antiviral agents. In this study, we present the synthesis and anti-SARS-CoV-2 activity of a series of benzocarbazoledinones, assessed using cell-based screening assays.

Selection of primary health care quality indicators in Europe: A Delphi study protocol.

Objective: To describe a protocol to achieve consensus on valid and important indicators to assess primary health care (PHC) quality regarding all clinical contexts of PHC in European health systems.

Study Design: Qualitative study using the Delphi technique to gain consensus among European panels of experts comprising a heterogeneous professional background.

Methods: Potential candidate indicators were extracted and translated according to a set of informative elements (i.

Socioeconomic factors increase the risk of teenage pregnancy: spatial and temporal analysis in a Brazilian municipality.

Objective: To evaluate the distribution of the proportion of teenage mothers (PTM) in time and space and its relationship with socioeconomic indicators and social vulnerability.

Methods: An ecological study was carried out with teenage mothers living in 322 census tracts in Foz do Iguaçu (state of Paraná, Brazil) between 2013 and 2019. Spatial clusters of teenage mothers were identified by spatial scanning and grouped into strata with different prevalence.