Publications by authors named "G M Chisolm"
Article Synopsis
- The study investigates gender disparities in financial ties between physicians and the medical industry, particularly focusing on payments from pharmaceutical and medical device companies.
- It found that female physicians received significantly less financial compensation than male physicians across various categories, including meal expenses, education, speaker fees, and sponsored research.
- The results suggest a need for standardized compensation practices to promote equity among physicians, especially as transparency in these financial relationships increases.
Exciting discoveries related to IL-1R/TLR signaling in the development of atherosclerosis plaque have triggered intense interest in the molecular mechanisms by which innate immune signaling modulates the onset and development of atherosclerosis. Previous studies have clearly shown the definitive role of proinflammatory cytokine IL-1 in the development of atherosclerosis. Recent studies have provided direct evidence supporting a link between innate immunity and atherogenesis.
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- - The study investigates the role of the STAT1 transcription factor in aortic degeneration and its involvement in abdominal aortic aneurysms (AAA) using both human samples and a mouse model.
- - Researchers infused angiotensin II into two types of mice (ApoE-/- and ApoE/STAT1-/-) and measured aortic aneurysm formation, blood pressure, and protein levels of STAT1 over time, finding a clear relationship between STAT1 levels and aortic pathology.
- - Results showed that STAT1 is linked to the severity of aneurysms, with ApoE/STAT1-/- mice exhibiting more frequent and larger aneurysms and higher rates of aortic rupture compared to ApoE-/- mice.
Lysophosphatidylcholine activates a novel PKD2-mediated signaling pathway that controls monocyte migration.
Arterioscler Thromb Vasc Biol
September 2009
Article Synopsis
- The study investigates how protein kinase D (PKD), particularly the PKD2 isoform, influences monocyte migration, which is important for conditions like atherosclerosis and inflammation.
- It found that lysophosphatidylcholine (lysoPC), a component of oxidized LDL, activates PKD2, which then triggers pathways that lead to monocyte movement.
- The research highlights PKD2's role in mediating cell migration through activation of the p38 MAPK pathway, suggesting its potential involvement in inflammatory disease development.