Publications by authors named "G M Callaghan"
Article Synopsis
- This study examines how amorphous materials behave when subjected to repeated shear stress using two models: a thermal elastoplastic model and a soft glassy rheology model.
- We observe that initially, these materials accumulate small amounts of damage slowly over many cycles, but eventually, this leads to a sudden failure characterized by strong strain localization, or shear banding.
- The research details how factors like strain amplitude, temperature, and pre-shear treatment affect the number of cycles before failure, and encourages further experiments to validate these predictions.
Article Synopsis
- Primary sclerosing cholangitis (PSC) is a chronic liver disease, and liver transplantation is the only established treatment; this study evaluates the effects of biologics in PSC patients with inflammatory bowel disease (IBD).
- A systematic review and meta-analysis of six studies (including 411 patients) found no significant change in alkaline phosphatase levels with biologics, but a small increase in total bilirubin and a notable response in ulcerative colitis symptoms.
- The study concludes that while biologics can help treat colitis associated with PSC, they do not improve liver biochemical markers and vedolizumab may worsen liver enzyme levels, indicating a need for more research.
Background: Catheter-related bloodstream infections (CRBSIs) in patients receiving home parenteral nutrition (HPN) for chronic intestinal failure (CIF) are associated with significant morbidity and financial costs. Taurolidine is associated with a reduction in bloodstream infections, with limited information on the cost-effectiveness as the primary prevention. This study aimed to determine the cost-effectiveness of using taurolidine-citrate for the primary prevention of CRBSIs within a quaternary hospital.
View Article and Find Full Text PDFThe differential diagnosis between autism and schizophrenia in childhood has been the subject of numerous controversies. Because verbal hallucinations could be one of the main clinical phenomena when establishing a differential diagnosis, the objective was to investigate the presence or absence of verbal hallucinations in autism. For this, a selective and unsystematic review of the current scientific evidence was carried out.
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