Publications by authors named "G M Ayers"
Introduction: Measurement of repeatability and reproducibility (R&R) is necessary to realize the full potential of positron emission tomography (PET). Several studies have evaluated the reproducibility of PET using 18F-FDG, the most common PET tracer used in oncology, but similar studies using other PET tracers are scarce. Even fewer assess agreement and R&R with statistical methods designed explicitly for the task.
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- The study investigates the relationship between body weight and leukopenia in solid organ transplant recipients on valganciclovir (VGC) prophylaxis to prevent cytomegalovirus disease.
- Over half (52%) of the patients developed leukopenia, with those having a higher starting weight (97.9 kg) less likely to experience it compared to lower-weight patients (90.7 kg).
- Results indicate that each 1 kg increase in body weight decreases the risk of leukopenia by about 1.7%, highlighting the importance of considering patient weight in VGC dosing.
In the era of precision oncology (PO), systemic therapies for patients (pts) with solid tumors have shifted from chemotherapy (CT) to targeted therapy (TT) and immunotherapy (IO). This systematic survey describes features of trials enrolling between 2010 and 2020, focusing on inclusion criteria, type of dose escalation scheme (DES) utilized, and use of expansion cohorts (ECs). A literature search identified phase I studies in adults with solid tumors published January 1, 2000- December 31, 2020 from 12 journals.
View Article and Find Full Text PDFPurpose: In the era of precision oncology (PO), systemic therapies for patients (pts) with solid tumors have shifted from chemotherapy (CT) to targeted therapy (TT) and immunotherapy (IO). This systematic survey describes features of trials enrolling between 2010-2020, focusing on inclusion criteria, type of dose escalation scheme (DES) utilized, and use of expansion cohorts (ECs).
Methods: A literature search identified phase I studies in adults with solid tumors published January 1, 2000 - December 31, 2020 from 12 journals.