Publications by authors named "G Lynch"
Purpose: Carbonic anhydrase IX (CAIX) is a well-established prognostic marker in breast cancer (BC). Nevertheless, this prognostic value is yet to be confirmed in BC subtypes. This study aims to investigate the prognostic effects of CAIX in oestrogen receptor (ER)-negative (ER-) BCs and to establish pathways related to cytoplasmic CAIX expression in ER- and lymph node-negative BCs.
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- Skeletal muscle has strong regenerative abilities thanks to muscle stem cells (MuSCs), which help repair and create new muscle fibers.
- Diabetes and other metabolic diseases can negatively affect MuSC health, leading to poor muscle regeneration and a condition known as diabetic myopathy, which complicates diabetes management.
- The text discusses how diabetes impacts MuSCs and muscle function, exploring the mechanisms behind these issues and potential solutions to improve muscle health in diabetic patients.
Quantifying the Time-course of Changes in Maximal Skin Wettedness with 7 days of Heat Acclimation.
J Appl Physiol (1985)
November 2024
The aim of the present study was to quantify the time-course of changes in maximum skin wettedness (ω) - i.e., the proportion of skin surface area covered in sweat at the point of uncompensable heat stress, throughout 7 consecutive days of heat acclimation.
View Article and Find Full Text PDFThe hippocampus is the most studied brain region but little is known about signal throughput -- the simplest, yet most essential of circuit operations -- across its multiple stages from perforant path input to CA1 output. Using hippocampal slices derived from male mice, we have found that single-pulse lateral perforant path (LPP) stimulation produces a two-part CA1 response generated by LPP projections to CA3 ('direct path') and the dentate gyrus ('indirect path'). The latter, indirect path was far more potent in driving CA1 but did so only after a lengthy delay.
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