Publications by authors named "G Lugthart"
Article Synopsis
- The study aimed to investigate the prevalence of Pediatric Post-COVID-19 Condition (PPCC), identify associated risk factors, and evaluate the quality of life in children based on the severity of their acute COVID-19 illness.
- A total of 579 children participated, with 260 experiencing mild COVID-19, 60 with severe disease, and 259 as a control group; results indicated that those with severe COVID-19 had a significantly higher prevalence of PPCC compared to mild cases and controls.
- Findings showed that while prevalence of PPCC decreased over time, children exhibiting PPCC had worse physical health-related quality of life and fatigue, with risk factors including prior health issues, hospitalizations, and ongoing fatigue one month post-infection.
Children with Multisystem Inflammatory Syndrome in Children (MIS-C) can present with thrombocytopenia, which is a key feature of hemophagocytic lymphohistiocytosis (HLH). We hypothesized that thrombocytopenic MIS-C patients have more features of HLH. Clinical characteristics and routine laboratory parameters were collected from 228 MIS-C patients, of whom 85 (37%) were thrombocytopenic.
View Article and Find Full Text PDFIntra-uterine reduction of Hb Bart's only reached with exchange transfusions.
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- A multicenter study from March 2020 to December 2022 evaluated pediatric COVID-19 cases, examining severity and risk factors in 564 hospitalized children across three countries.
- Among the hospitalized children, those over 12 and with preexisting respiratory issues were more likely to experience severe illness, while cases during the omicron variant showed milder symptoms overall.
- The study emphasizes that real-time data collection is crucial for guiding public health decisions, including vaccine and booster strategies for children infected with SARS-CoV-2.
Human natural killer (NK) cells in lymphoid tissues can be categorized into three subsets: CD56CD16, CD56CD16 and CD69CXCR6 lymphoid tissue-resident (lt)NK cells. How the three subsets are functionally and developmentally related is currently unknown. Therefore, we performed single-cell RNA sequencing combined with oligonucleotide-conjugated antibodies against CD56, CXCR6, CD117 and CD34 on fresh bone marrow NK cells.
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