Publications by authors named "G Lucci"

Article Synopsis
  • COPD is a chronic inflammatory lung disease, and there's a need for new anti-inflammatory treatments, particularly those targeting the PI3K pathway, with CHF6523 being an inhaled PI3Kδ inhibitor showing promise in preliminary tests.
  • The study involved 44 patients with stable COPD, using a randomized double-blind design with two treatment phases over 28 days each, to evaluate the safety, tolerability, and pharmacokinetics of CHF6523 compared to a placebo.
  • Results indicated that CHF6523 effectively reduced a key inflammatory marker (PIP) by 29.7% from baseline, with pharmacokinetic data suggesting limited drug accumulation and quick absorption after inhalation.
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In the processing of emotions, the brain prepares and reacts in distinctive manners depending upon the negative or positive nuance of the emotion elicitors. Previous investigations showed that negative elicitors generally evoke more intense neural activities than positive and neutral ones, as reflected in the augmented amplitude of all sub-components of the event-related potentials (ERP) late posterior positivity (LPP) complex, while less is known about the emotion of disgust. The present study aimed to examine whether the LPP complex during the processing of disgust stimuli showed greater amplitude than other emotion elicitors with negative or positive valences, thus confirming it as a neural marker of disgust-related negativity bias at earlier or later stages.

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The key role of electro-chemical signals in cellular processes had been known for many years, but more recently the interplay with mechanics has been put in evidence and attracted substantial research interests. Indeed, the sensitivity of cells to mechanical stimuli coming from the microenvironment turns out to be relevant in many biological and physiological circumstances. In particular, experimental evidence demonstrated that cells on elastic planar substrates undergoing periodic stretches, mimicking native cyclic strains in the tissue where they reside, actively reorient their cytoskeletal stress fibres.

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Article Synopsis
  • - A patient was found to have a chronic subdural/epidural hematoma along with a large arachnoid cyst in the left frontotemporal area, which were discovered while investigating trigeminal neuralgia and memory issues.
  • - The patient's sudden audioverbal memory impairment is thought to be related to disruptions in brain function due to the hematoma, affecting structures that help regulate arousal.
  • - This case suggests that even with damage to one hemisphere of the brain, audioverbal memory can be compromised without relying on the intact hemisphere, indicating a potential limit for reorganization of memory functions between hemispheres.
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Brain tumours are among the deadliest types of cancer, since they display a strong ability to invade the surrounding tissues and an extensive resistance to common therapeutic treatments. It is therefore important to reproduce the heterogeneity of brain microstructure through mathematical and computational models, that can provide powerful instruments to investigate cancer progression. However, only a few models include a proper mechanical and constitutive description of brain tissue, which instead may be relevant to predict the progression of the pathology and to analyse the reorganization of healthy tissues occurring during tumour growth and, possibly, after surgical resection.

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