Publications by authors named "G Luca Gusella"
Assays that measure morphology, proliferation, motility, deformability, and migration are used to study the invasiveness of cancer cells. However, native invasive potential of cells may be hidden from these contextual metrics because they depend on culture conditions. We created a micropatterned chip that mimics the native environmental conditions, quantifies the invasive potential of tumor cells, and improves our understanding of the malignancy signatures.
View Article and Find Full Text PDFPestalotioid fungi were isolated in pure culture from symptomatic plants of , , (marketed as ""), Myrtuscommunissubsp.tarentina, and M.communisvar.
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- Patients with autosomal dominant polycystic kidney disease (ADPKD) exhibit complement activation, but its role in kidney cyst growth was previously unclear.
- Research using a specific cell line and genetically modified mice showed that lack of the Pkd1 gene leads to increased complement-related genes and faster cyst formation, while its absence delayed cyst growth and reduced inflammation.
- The study suggests that the downregulation of complement regulators due to Pkd1 loss enhances cystogenesis through C5a activation, indicating a potential new target for therapeutic interventions in ADPKD.
COVID-19 has been a significant public health concern for the last four years; however, little is known about the mechanisms that lead to severe COVID-associated kidney injury. In this multicenter study, we combined quantitative deep urinary proteomics and machine learning to predict severe acute outcomes in hospitalized COVID-19 patients. Using a 10-fold cross-validated random forest algorithm, we identified a set of urinary proteins that demonstrated predictive power for both discovery and validation set with 87% and 79% accuracy, respectively.
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