Publications by authors named "G Lori"
Chlorpyrifos (CPF) is an organophosphorus pesticide of concern because many in vivo animal studies have demonstrated developmental toxicity exerted by this substance; however, despite its widespread use, evidence from epidemiological studies is still limited. In this study, we have collected all the information generated in the twenty-first century on the developmental toxicity of CPF using new approach methodologies. We have critically evaluated and integrated information coming from 70 papers considering human, rodent, avian and fish models.
View Article and Find Full Text PDFCancer cachexia is a multifactorial syndrome characterized by a progressive loss of body weight occurring in about 80% of cancer patients, frequently representing the leading cause of death. Dietary intervention is emerging as a promising therapeutic strategy to counteract cancer-induced wasting. Serine is the second most-consumed amino acid (AA) by cancer cells and has emerged to be strictly necessary to preserve skeletal muscle structure and functionality.
View Article and Find Full Text PDFArticle Synopsis
- Research Focus
- : The study investigates how fatty acid metabolism impacts stem-like characteristics in intrahepatic cholangiocarcinoma (iCCA), a serious type of liver cancer.
- Key Findings
- : Cancer cells with stem-like features (SPH) have higher levels of free fatty acids and lipid synthesis enzymes compared to regular cells. Inhibition of fatty acid synthase (FASN) reduces these stem characteristics and tumor growth in lab models.
- Clinical Implications
- : Targeting fatty acid metabolism could provide new strategies for treating iCCA, potentially improving patient survival and slowing disease progression.
Article Synopsis
- Microglia, the immune cells in the brain, contribute to neuroinflammation and aging, both of which increase the risk of neurodegenerative disorders like Alzheimer's disease (AD).
- This study examines the effects of Honokiol (HNK), a natural compound, and its synthetic version, Honokiol Hexafluoro (CH), on reducing inflammation and cellular aging in microglia cells.
- Results show that both HNK and CH effectively reduce harmful inflammation, improve anti-inflammatory responses, and inhibit markers of cellular senescence, suggesting their potential as therapeutic agents in treating age-related neurodegenerative diseases.
Chlorpyrifos (CPF) is a widely used pesticide inducing adverse neurodevelopmental and reproductive effects. However, knowledge of the underlying mechanisms is limited, particularly in the hypothalamus. We investigated the mode of action of CPF at human relevant concentrations (1 nM-100 nM) in immortalized mouse hypothalamic GnRH neurons (GT1-7), an elective model for studying disruption of the hypothalamus-pituitary-gonads (HPG) axis.
View Article and Find Full Text PDF