Publications by authors named "G Lopez-Valladares"
Premature stop codons in the internalin virulence determinant are common in serotype 1/2a from food/food processing environments but rare among human clinical isolates. Here, we report the genome sequences of serotype 1/2a (STs 121 and 3258) human listeriosis isolates from Sweden harboring such mutations in .
View Article and Find Full Text PDFListeria monocytogenes of clonal complex 14 (CC14) is a potentially hypervirulent clone of serotype 1/2a but remains poorly characterized. We report the genome sequences of five sequence type 14 (ST14) (CC14) strains from human listeriosis cases in Sweden, which harbor a chromosomal heavy metal resistance island that is generally uncommon in serotype 1/2a.
View Article and Find Full Text PDFArticle Synopsis
- The text discusses a Gram-positive bacterium that causes listeriosis and focuses on a specific genomic region called the immigration control region (ICR), which contains various restriction modification (RM) systems.
- Analysis of 872 genomes revealed that 86.1% contained RM systems in the ICR region, contributing to the stability and emergence of new bacterial strains (sequence types).
- The presence of certain RM systems, like the Sau3AI-like type II system, may reflect adaptations that influence the bacterium's resistance to bacteriophages, which plays a role in its survival and diversification.
Listeriosis is a foodborne disease with a high fatality rate, and infection is mostly transmitted through ready-to-eat (RTE) foods contaminated with Listeria monocytogenes, such as gravad/smoked fish, soft cheeses, and sliced processed delicatessen (deli) meat. Food products/dishes stored in vacuum or in modified atmospheres and with extended refrigerator shelf lives provide an opportunity for L. monocytogenes to multiply to large numbers toward the end of the shelf life.
View Article and Find Full Text PDFAmong 504 clinical lineage II isolates of Listeria monocytogenes isolated during 1958-2010 in Sweden, 119 pulsed-field gel electrophoresis (PFGE) types (AscI) have been identified based on the number and distribution of all banding patterns in each DNA profile. In this study, these types were further divided into PFGE groups based on the configuration of small bands with sizes <145.5 kb.
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