N to N Isotopic Exchange of Nitrogen Heteroaromatics through Skeletal Editing.

The selective modification of nitrogen heteroaromatics enables the development of new chemical tools and accelerates drug discovery. While methods that focus on expanding or contracting the skeletal structures of heteroaromatics are emerging, methods for the direct exchange of single core atoms remain limited. Here, we present a method for N → N isotopic exchange for several aromatic nitrogen heterocycles.

Skeletal Editing of Pyrimidines to Pyrazoles by Formal Carbon Deletion.

A method for the conversion of pyrimidines into pyrazoles by a formal carbon deletion has been achieved guided by computational analysis. The pyrimidine heterocycle is the most common diazine in FDA-approved drugs, and pyrazoles are the most common diazole. An efficient method to convert pyrimidines into pyrazoles would therefore be valuable by leveraging the chemistries unique to pyrimidines to access diversified pyrazoles.

Localized short impulses in a nerve model with self-excitable membrane.

During the generation and transmission of nerve impulses, the cytoplasm behaves like an excitable medium that self-regulates the shapes and magnitudes of the output excitation. In connection with this self-regulatory function, one can readily think of the plasma membrane as a nerve organ holding the key role in the mechanisms of generation and transmission of the transmembrane potential, namely, it is expected to provide the essential feedback that stabilizes the stimulus. Here, a simple and coherent picture of self-regulation of the nerve impulse is proposed in terms of one single feedback associated with the main excitable biological organ of the nervous system.

Synthesis and utilization of perylene-based n-type small molecules in light-emitting electrochemical cells.

We report the synthesis of a soluble perylene-based small molecule for use as an n-type emissive material for organic optoelectronic device applications, and demonstrate the material in a light-emitting electrochemical cell configuration.