Percutaneous nephrolithotomy in children.

Percutaneous nephrolithotomy was performed on 18 children with renal calculi. No mortality resulted from this procedure and hemorrhage was the major complication. At the end of treatment 67% of the patients were stone-free and 82% of targeted stones were removed.

Clinical evaluation of flutamide and estramustine as initial treatment of metastatic carcinoma of prostate.

The efficacy and side effects of flutamide were compared with estramustine in patients with advanced prostatic carcinoma. Thirty patients with metastatic cancers but with no serious cardiovascular (CV) conditions were randomly assigned to receive treatment either with flutamide (250 mg X 3) or with estramustine (280 mg X 2). Clinical examination, bone scan, laboratory measurements, including coagulation studies were performed prior to randomization, every three months during year one, and at six-month intervals thereafter.

Bladder function in spinal anaesthesia.

Spinal anaesthesia with bupivacaine (22.5 mg) or with a glucose-containing solution of bupivacaine (20 mg) or tetracaine (15 mg) was given to 21 patients allocated randomly to these three groups. A urodynamic study was performed by CO2 cystometry.

High-dose medroxyprogesterone in the treatment of advanced therapy-resistant prostatic carcinoma.

In a preliminary study we have administered medroxyprogesterone acetate to 20 patients with advanced metastatic prostatic cancer, who no longer responded to previous therapy. The dose used was 1,000 mg intramuscularly three times a week for 5 weeks, followed by 1,000 mg weekly until progression. All patients had undergone orchidectomy or had been treated with estrogens.