Publications by authors named "G Lindop"

Article Synopsis
  • Organelles create membrane contact sites for molecule and signal transfer, with mitochondria-endoplasmic reticulum contact sites (MERCS) playing a key role in various diseases, including neurodegenerative disorders.
  • A genome-wide screen identified 410 genes that regulate MERCS, with 29 genes chosen for further analysis; particularly, GET4 and BAG6 were found to significantly influence MERCS when suppressed.
  • Investigating GET4 and BAG6 revealed that their loss increases MERCS and enhances mitochondrial function, while also showing neuroprotective effects in a Drosophila model of Alzheimer's disease.
View Article and Find Full Text PDF

Objective: Cerebral aneurysms of an infectious etiology, so-called "mycotic" aneurysms, are rare neurovascular pathologies. Primary treatment may be targeted on the aneurysm, but care has to be driven by the underlying pathology to prevent an often fatal clinical course with a mortality rate reaching 90%. 2 case reports are presented, and the diagnostic and therapeutic issues outlined by reviewing the literature.

View Article and Find Full Text PDF

Background: Young (4 week) spontaneously hypertensive rats (SHR) exhibit greater renal responses to angiotensin II (Ang II) than normotensive Wistar Kyoto (WKY) rats. SHR pups cross-fostering to a WKY dam at birth (SHRX) are less sensitive to Ang II and have lower adult blood pressure. The aim of this study was to compare renal renin-angiotensin system activity in young naturally reared and cross-fostered SHR pups.

View Article and Find Full Text PDF

Both global and segmental glomerulopathies may damage specific areas of the renal glomerulus. Diseases associated with glomerular hyperperfusion cause lesions at the vascular pole, while diseases associated with proteinuria often damage the tubular pole. Atubular glomeruli are now known to be plentiful in a variety of common renal diseases.

View Article and Find Full Text PDF

We describe a case of benign ectopic thyroid tissue found attached to the ascending aorta at operation.

View Article and Find Full Text PDF