Publications by authors named "G Libeau"
Peste des petits ruminants virus (PPRV) causes a highly infectious disease affecting mainly goats and sheep in large parts of Africa, Asia, and the Middle East and has an important impact on the global economy and food security. Full genome sequencing of PPRV strains has proved to be critical to increasing our understanding of PPR epidemiology and to inform the ongoing global efforts for its eradication. However, the number of full PPRV genomes published is still limited and with a heavy bias towards recent samples and genetic Lineage IV (LIV), which is only one of the four existing PPRV lineages.
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- Peste des petits ruminants (PPR) is a viral disease affecting mainly sheep and goats, but can also infect other animals like buffalos and camels, highlighting concerns about how the virus spreads between wildlife and livestock.
- Validated serological tools, such as the virus neutralisation test (VNT) and enzyme-linked immunosorbent assay (ELISA), have been used to detect previous infections but their effectiveness for atypical species is still uncertain.
- A study analyzing 793 serum samples found that while VNT and ELISAs showed a high agreement (75-88%) for typical species, the accuracy dropped significantly (44-62%) for atypical species, indicating a need for better diagnostic approaches in these cases.
Article Synopsis
- The production of peste des petits ruminants (PPR) vaccines in Russia relies on two virus strains, "45G37/35-k" and "ARRIAH," which are of common origin.
- A full genome analysis of the PPRV/45G37/35-k strain revealed it is related to the established vaccine strain Nigeria/75/1, but with 248 nucleotide differences, suggesting it is a distinct, unrecognized strain.
- The safety and effectiveness of the Russian vaccine strains need to be thoroughly documented and submitted to the World Organization for Animal Health (WOAH) before they can be distributed widely.
Peste des petits ruminants (PPR) is an acute disease of small ruminants caused by a morbillivirus. Clinical observation of the disease in the field revealed that several species of small ruminants are affected to varying degrees. This difference in disease-related effects could depend either on the host or on the virulence of the virus strain.
View Article and Find Full Text PDFIntroduction: In recent years Peste des petits ruminants (PPR) disease caused several epidemics in a wide range of susceptible hosts. The ability of the peste des petits ruminants virus (PPRV) to cross the species barrier necessitates further research, particularly on disease circulation and cross-species transmission between typical and atypical hosts to guide and facilitate the eradication program anticipated by the Food and Agriculture Organization (FAO) and the World Organization for Animal Health (OIE) in 2030. The aim of this study is to explore the role of dromedary camels as transmitters for PPR.
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