Publications by authors named "G Li Volti"
Background: Micro-RNAs (miRNAs) have been reported to play an important role during orthodontic tooth movement (OTM) through the regulation of periodontal soft and hard tissue homeostasis and functions. The aim of the present study was to assess the effects of miRNAs on OTM and to evaluate possible predictors that influenced the overall OTM amount at a 3-month follow-up.
Methods: Through a split-mouth design, 21 healthy patients (mean age 13.
Article Synopsis
- * A study using a DS mouse model (Ts2Cje) showed that these mice experience heightened liver oxidative stress, reduced antioxidant defenses, and changes in inflammatory response and mitochondrial health, indicating serious liver issues.
- * The liver in DS mice exhibited signs of non-alcoholic fatty liver disease due to dysregulated lipid metabolism and fibrosis, suggesting a significant risk for liver-related complications in individuals with DS, emphasizing the need for potential therapeutic strategies.
Article Synopsis
- - GNAO1 encephalopathy involves severe neurological symptoms like hypotonia, psychomotor retardation, and movement disorders, linked to genetic variations like the E246K mutation in the Gα subunit affecting G protein signaling.
- - Molecular modeling studies were used to explore the impact of the E246K mutation on G protein signal transduction and test the effectiveness of the drug tetrabenazine in addressing these abnormalities.
- - Results showed that tetrabenazine could normalize signal transduction affected by the E246K mutation, suggesting it might be a viable treatment for pediatric patients with this rare form of encephalopathy.