Publications by authors named "G Lessa"
Article Synopsis
- Maternal infections, notably Zika virus (ZIKV), are key risk factors for cognitive impairments in offspring, causing various birth defects, including microcephaly.
- Research shows that Ndel1 oligopeptidase activity is reduced in the forebrain of ZIKV-infected animal models, correlating with brain size and suggesting it could serve as a biomarker for microcephaly.
- Increasing interferon (IFN)-beta signaling showed potential in restoring Ndel1 activity and improving outcomes of ZIKV infection, highlighting Ndel1's role in understanding and monitoring congenital syndromes linked to ZIKV.
Paracoccidioidomycosis (PCM) is one of the most frequent systemic mycoses in Latin America. It affects mainly male rural workers in impoverished regions, and the therapy can last up to two years or use drugs that are very toxic. Given the need for novel safe and effective approaches to treat PCM, we have been developing monoclonal antibodies (mAbs) that could be used not only to block specific fungal targets, but also modulate the host's antifungal immunity.
View Article and Find Full Text PDFNEOTROPICAL ALIEN MAMMALS: a data set of occurrence and abundance of alien mammals in the Neotropics.
Ecology
November 2020
Biological invasion is one of the main threats to native biodiversity. For a species to become invasive, it must be voluntarily or involuntarily introduced by humans into a nonnative habitat. Mammals were among first taxa to be introduced worldwide for game, meat, and labor, yet the number of species introduced in the Neotropics remains unknown.
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