Publications by authors named "G Lencioni"
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses of all common solid cancers. For the large majority of PDAC patients, only systemic therapies with very limited efficacy are indicated. In addition, immunotherapies have not brought the advances seen in other cancer types.
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- Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer that often goes undiagnosed until advanced stages, resulting in limited treatment options primarily focused on chemotherapy, which patients frequently build resistance to.
- The complexity of PDAC, characterized by genetic mutations and a challenging tumor microenvironment, makes it difficult to find innovative treatment solutions, highlighting the need for effective models to study these factors.
- Recent advancements in research models, such as organoids and 3D bioprinting, are providing valuable insights into PDAC biology and drug resistance, aiming to enhance therapeutic strategies and improve patient outcomes.
Article Synopsis
- CoRSIVs are regions in the genome with consistent DNA methylation patterns across tissues but show individual differences and are influenced by nearby genetic variants.
- This study focused on investigating SNPs within CoRSIVs and their potential link to pancreatic ductal adenocarcinoma (PDAC) risk, analyzing data from over 14,000 patients and 247,000 controls.
- The research identified that the A allele of SNP rs2976395 is linked to a higher risk of PDAC in Europeans and is associated with changes in DNA methylation and overexpression of the prostate stem cell antigen gene, highlighting the need for further functional studies.
Introduction: Only a small number of risk factors for pancreatic ductal adenocarcinoma (PDAC) has been established. Several studies identified a role of epigenetics and of deregulation of DNA methylation. DNA methylation is variable across a lifetime and in different tissues; nevertheless, its levels can be regulated by genetic variants like methylation quantitative trait loci (mQTLs), which can be used as a surrogate.
View Article and Find Full Text PDFThe article describes: growth phenotypes of the four plant species () before and after the treatment with ionic and nanoscale Zn and Cd (Fig. 1); the method of synthesis and characterization of ZnS QDs and CdS QDs (Fig. 2); the genetic characterization (performed with molecular markers) of the four plant species, their relative genecological relation (Fig.
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