Publications by authors named "G Lemasson"
Purpose: To prospectively assess the impact of expert pathological review of skin adnexal carcinoma diagnosis in France.
Methods: From 2014 to 2019, 2573 samples from patients with newly diagnosed or suspected skin adnexal carcinomas were reviewed prospectively by expert pathologists through the national CARADERM (CAncers RAres DERMatologiques) network. Changes in diagnosis between referral and expert review were analysed regarding their potential impact on patient care or prognosis.
Article Synopsis
- Myasthenia gravis (MG) - Lambert-Eaton (LE) overlap syndrome, a rare condition, was identified in a patient undergoing treatment for metastatic melanoma with the drug nivolumab, an anti-PD1 inhibitor.
- The patient experienced symptoms such as fatigue, ptosis, and swallowing difficulties after receiving nivolumab, which led to the diagnosis through various antibody tests and electromyogram findings.
- Despite halting nivolumab and administering immunosuppressive treatment that improved the symptoms, a relapse occurred two years later, suggesting potential links between brain inflammation from radiation therapy and the onset of MG-LE overlap syndrome.
PD-L1 expression in recurrent head and neck squamous cell carcinoma.
Eur Arch Otorhinolaryngol
January 2022
Purpose: To evaluate the Programmed Cell Death Ligand (PD-L1) expression at diagnosis and relapse in patients with head and neck carcinoma (HNSCC) treated with radio(chemo)therapy.
Methods: PD-L1 immunohistochemistry was performed in tumor cells (TC) and immune cells (IC) in 44 patients and scored as 0 = 0%, 1 = < 5%, 2 = 6-49% or 3 = ≥ 50% cells.
Results: PD-L1 expression on TC before RT was scored as 0, 1, 2 and 3 in 28, 4, 8 and 4 patients, respectively.
In 90% of Amyotrophic Lateral Sclerosis (ALS) cases, the disease is sporadic, the remaining 10% being familial. Many genes have been associated with the disease. The use of next generation sequencing has allowed increasing the number of genes analysed in routine diagnostics.
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