Publications by authors named "G Lefebvre"
This work explores two methods to encapsulate Thymoquinone (TQ) into lipid nanocapsules (LNCs) for oral administration. TQ was added during the phase inversion temperature method (TQ-LNCs-1) or to unload LNCs dispersion (TQ-LNCs-2). LNCs were evaluated for mean diameter, polydispersity index (PDI), ζ-potential, drug loading (DL), drop tensiometer, storage stability, stability in simulated gastrointestinal fluids (SGIF), and intestinal permeability across Caco-2 cells.
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- Congenital titinopathies are inherited in an autosomal recessive pattern and primarily result from genetic variations in metatranscript (MTT)-only exons, leading to diverse clinical outcomes.
- The study analyzed 20 patients with these variants, revealing severe congenital myopathy at birth along with a wide range of associated issues like muscular weakness and respiratory problems.
- Findings underscore the importance of genotype-phenotype correlations, enhancing understanding of the genetic basis and molecular mechanisms behind these conditions.
Article Synopsis
- The article presents the first successful creation of SF-ynamides, which are multifunctional compounds incorporating a pentafluorosulfanyl group.
- * The synthesis involves a two-step process: first, a radical reaction adds the SF group to different terminal ynamides, followed by removing a chlorine atom.
- * Various chemical reactions can readily modify these newly formed SF-ynamides, demonstrating their potential for diverse applications in organic chemistry.
Continuous professional development (CPD) is crucial for physicians to maintain and enhance their skills. In response to the changing context of CPD and health care, this study applied a design thinking approach to transform and modernise the Royal College of Physicians and Surgeons of Canada's Maintenance of Certification (MOC) Program. A member-wide survey and co-design sessions with physicians, CPD leaders, and patient representatives were conducted, emphasising the importance of their insights and experiences.
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- This study examined postoperative pain management practices in women undergoing hysterectomy in Austria and Canada, focusing on opioid prescribing differences amid the opioid epidemic.
- It found that while total morphine equivalent doses (MED) were similar across both countries, Austria administered higher MED during surgery but significantly lower MED within the first 24 hours post-op compared to Canada.
- The findings suggest cultural attitudes towards pain management heavily influence prescribing practices, as evidenced by the stark contrast in discharge opioid prescriptions (98.5% in Canada vs. 0% in Austria), highlighting the need for further research in this area.