Attempts to enhance kidney allografts in DLA-identical dogs with specific anti-IA-like sera.

Attempts at enhancement of kidney allografts in DLA-identical dogs by injection of specific antidonor Ia-like antibodies or IgG are reported. Anti Ia-like sera were raised by immunization with allogeneic, splenocytes and subsequently adsorbed on platelets from the immunizing dog. Platelets were obtained from an average of 20 plasmaphoreses of each immunizing dog and from a pool of random mongrel dogs.