Publications by authors named "G Le Gall"
At cellular and circuit levels, drug addiction is considered a dysregulation of synaptic plasticity. In addition, dysfunction of the glutamate transporter 1 (GLT-1) in the nucleus accumbens (NAc) has also been proposed as a mechanism underlying drug addiction. However, the cellular and synaptic impact of GLT-1 alterations in the NAc remain unclear.
View Article and Find Full Text PDFHumans may play a key role in providing small prey mammals spatial and temporal refuge from predators, but few studies have captured the heterogeneity of these effects across space and time. Global COVID-19 lockdown restrictions offered a unique opportunity to investigate how a sudden change in human presence in a semi-urban park impacted wildlife. Here, we quantify how changes in the spatial distributions of humans and natural predators influenced the landscape of fear for the California ground squirrel (Otospermophilus beecheyi) in a COVID-19 pandemic (2020) and non-COVID (2019) year.
View Article and Find Full Text PDFThe gut microbiota-brain axis has been associated with the pathogenesis of numerous disorders, but the mechanism(s) underlying these links are generally poorly understood. Accumulating evidence indicates the involvement of gut microbe-derived metabolites. Circulating levels of the gut microbe/host co-metabolite -cresol sulfate (pCS) correlate with cerebrovascular event risk in individuals with chronic kidney disease (CKD), but whether this relationship is mechanistic is unclear.
View Article and Find Full Text PDFArticle Synopsis
- This study explores how (poly)phenols, particularly from grape and blueberry extracts (Memophenol™), can impact gut health and brain function amid chronic inflammation.
- The research found that Memophenol™ can reduce harmful gut-derived compounds (indoxyl sulfate and trimethylamine N-oxide) linked to inflammation, and it alters the gut microbiome composition in mice.
- Furthermore, Memophenol™ intake helped maintain the integrity of brain blood vessel junctions and reduced markers related to neurodegeneration, suggesting its potential protective effects on both gut microbiota and brain health.
Background: Objective Structured Clinical Examinations (OSCEs) aim to assess medical students' clinical skills rather than just their theoretical knowledge. We propose a study between the learning style of second-cycle medical students and their performance in OSCEs.
Methods: During their internship at our hospital, students were invited to complete the LSQ-Fa, a questionnaire designed to identify their preferences among 4 learning styles: active, reflective, theoretical, and pragmatic.