Large-scale evaluation of outcomes after a genetic diagnosis in children with severe developmental disorders.

Purpose: We sought to evaluate outcomes for clinical management after a genetic diagnosis from the Deciphering Developmental Disorders study.

Methods: Individuals in the Deciphering Developmental Disorders study who had a pathogenic/likely pathogenic genotype in the DECIPHER database were selected for inclusion ( = 5010). Clinical notes from regional clinical genetics services notes were reviewed to assess predefined clinical outcomes relating to interventions, prenatal choices, and information provision.

Frequent, heterogenous fire supports a forest owl assemblage.

Fire shapes biodiversity in many forested ecosystems, but historical management practices and anthropogenic climate change have led to larger, more severe fires that threaten many animal species where such disturbances do not occur naturally. As predators, owls can play important ecological roles in biological communities, but how changing fire regimes affect individual species and species assemblages is largely unknown. Here, we examined the impact of fire severity, history, and configuration over the past 35 years on an assemblage of six forest owl species in the Sierra Nevada, California, using ecosystem-scale passive acoustic monitoring.

A trauma-informed approach to type 1 diabetes mellitus in adults.

Suggested mechanisms for an association between early life adversity and worse glycaemic control.

Indications for the addition of a patellofemoral joint arthroplasty following a previous unicondylar knee arthroplasty- a literature review and Delphi consensus.

Introduction: The aim of this study was to establish an international consensus statement on the indications for the addition of a patellofemoral joint arthroplasty (PFJA) in patients with a unicondylar knee arthroplasty (UKA) and symptomatic progression of patellofemoral compartment osteoarthritis.

Materials And Methods: A systematic review of the literature was conducted, and the results used to inform the development of a statement by an expert working group. This was then evaluated and modified, using a Delphi process, by members of the European Knee Society (EKS).

Sieving the weeds from the grains: an R based package for classifying archaeobotanical samples of cereals and pulses according to crop processing stages.

Unlabelled: The R package CropPro is an open-access resource to classify archaeobotanical samples as products and by-products of different stages of the crop processing sequence for large-seeded cereal and pulse crops in south west Asia, Europe and other Mediterranean regions. It builds on ethnographic research and analysis conducted by Jones (Plants and ancient man: studies in palaeoethnobotany. Balkema, Rotterdam, pp 43-61, 1984), (J Archaeol Sci 14:311-323, 1987), (Circaea 6:91-96, 1990) and a modified method by Charles (Environ Archaeol 1:111-122, 1998).