From Centimeters to Millimeters: The Evolution of the Surgical Margins for Melanoma-A Historical Review.

Background: With an improved understanding of tumor biology and behavior, the recommended margins for the surgical treatment of melanoma have evolved.

Objective: We describe the progression of these surgical margins, detailing the historical basis for the 5-cm margin and transitioning to current practice, in which Mohs micrographic surgery (MMS) with immunohistochemistry (IHC) has become increasingly used.

Methods/materials: We searched PubMed and Google Scholar for articles published between January 2019 and April 2023 describing the use of MMS for melanoma in situ (MIS) and invasive melanomas.

Sonic Hedgehog Pathway Inhibition in the Treatment of Advanced Basal Cell Carcinoma.

Advanced basal cell carcinoma (BCC) represents a small proportion of BCCs that are not amenable to standard therapies due to lack of efficacy, high recurrence risk, and excessive morbidity. Implication of the Sonic hedgehog (Shh) pathway in the development of BCC has led to the development of systemic Shh pathway inhibitors, providing patients with advanced BCCs new treatment options and improved survival. There are currently two Food and Drug Administration (FDA)-approved Shh inhibitors, vismodegib and sonidegib, for advanced basal cell carcinomas.

Overview of Kybella (Deoxycholic Acid Injection) as a Fat Resorption Product for Submental Fat.

There has been an increasing interest in addressing the issue of submental fat (SMF) when it comes to cosmetic medicine. With the rise of social media, video calls, and the now almost omnipresent accessibility of cameras, there is perhaps now more than ever an emphasis on the facial image. Although invasive procedures such as liposuction and neck lift still play a significant role in reducing SMF, the trend toward minimally invasive methods has finally given rise to a single Food and Drug Administration-approved injectable that is both safe and effective: ATX-101, also known as Kybella in the United States.