Publications by authors named "G Lagathu"
Article Synopsis
- The study compared two strategies for preventing cytomegalovirus (CMV) infections in high-risk liver transplant recipients: prophylaxis (P) and pre-emptive strategy (PS).
- Results showed significantly more patients in the PS group developed CMV DNAemia compared to the P group, although the overall rate of CMV disease was similar.
- Despite PS having a higher cost and longer treatment duration, both strategies had similar survival rates, but PS led to more cases of ganciclovir-resistant CMV.
Introduction: Cytomegalovirus (CMV) is the most frequent infectious complication following solid organ transplantation. Torque teno viruses (TTV) viremia has been proposed as a biomarker of functional immunity in the management of kidney transplant recipients (KTR). The QuantiFERON-CMV (QF-CMV) is a commercially available assay that allows the assessment of CD8 T-cell responses in routine diagnostic laboratories.
View Article and Find Full Text PDFMolecular biology amplification enables sensitive detection of most respiratory viruses through nasopharyngeal swabbing. We developed an innovative approach to detect viral genomes on used facial tissues. In 2 communities of children, used tissues were collected once weekly for 1 year.
View Article and Find Full Text PDFArticle Synopsis
- - Inhaled corticosteroids (ICS) have been linked to a higher risk of pneumonia and may also increase susceptibility to respiratory viral infections, particularly adenovirus and respiratory syncytial virus (RSV).
- - A study analyzed 2,658 adults hospitalized with influenza-like illness from 2012-2018, where 20.2% were treated with ICS prior to admission, with 52.5% testing positive for respiratory viruses.
- - Patients on ICS had a greater likelihood of complications, with 55.9% experiencing issues like pneumonia, a 14.2% ICU admission rate, and a 2.8% in-hospital mortality rate.
Objectives: The purpose of this study was to describe the clinical characteristics and in-hospital and post-discharge outcomes of respiratory syncytial virus (RSV) infection among adults hospitalised with influenza-like illness (ILI) and compared against patients admitted for influenza.
Methods: Adults hospitalised with ILI were prospectively included from five French university hospitals over two consecutive winter seasons (2017/2018 and 2018/2019). RSV and influenza virus were detected by multiplex reverse transcription PCR on nasopharyngeal swabs.